Telemetric

Capsules

The application of telemetric capsules offers various opportunities in oral biopharmaceutics.  Due to the recent progress in developing supporting techno-logies and the improved accessibility of certified commercial products, the interest into this in vivo technique has increased in the last years . We are using wireless motility capsules to characterize the transit conditions of oral dosage forms in the GI tract of humans and animals. By this, we are able to determine luminal pH, temperature and pressure values in high temporal resolution. These data form the basis of our biorelevant in vitro tools.

Publications:

  1. M. Koziolek, M. Grimm, T.  Bollmann, K. J. Schäfer, S. M. Blattner, R. Lotz, G. Boeck, W. Weitschies. Characterization of the GI transit conditions in Beagle dogs with a telemetric motility capsule. Eur. J. Pharm. Biopharm. 136 (2019) 221-230

  2. F. Schneider, R. Beeck, M. Hoppe, M. Koziolek, W. Weitschies. In vitro simulation of realistic gastric pressure profilesEur. J. Pharm. Sci. 30 (2017) 71-77

  3. T. Hildebrandt, E. Scheuch, W. Weitschies, M. Grimm, F. Schneider, L. Bachmann, I. Vervuert. Measurement of abomasal conditions (pH, pressure and temperature) in healthy and diarrheic dairy calves using a wireless ambulatory capsuleLivest. Sci. 203 (2017) 41-47​

  4. F. Schneider, M. Grimm, M. Koziolek, C. Modeß, A. Dokter, T. Roustom, W. Siegmund, W. Weitschies. Resolving the physiological conditions in bioavailability and bioequivalence studies: Comparison of fasted and fed stateEur. J. Pharm. Biopharm. 108 (2016) 214-219

  5. M. Koziolek, F. Schneider, M. Grimm, C. Modeβ, A. Seekamp, T. Roustom, W. Siegmund, W. Weitschies. Intragastric pH and pressure profiles after intake of the high-caloric, high-fat meal as used for food effect studiesJ. Control. Release 220 (2015) 71-81

  6. M. Koziolek, M. Grimm, D. Becker, V. Iordanov, H. Zou, J. Shimizu, C. Wanke, G. Garbacz, W.  Weitschies. Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap® SystemJ. Pharm. Sci. 104 (2015) 2855-2863

Institute of Pharmacy

 UNiversity of Greifswald 

Germany